Analysis of clinical and molecular data shows that activated ERα form was an independent factor for sensitivity to chemoendocrine treatment, whereas HIF-1α and p44/42 MAPK were independent factors for resistance. Although further confirmatory analyses are needed, these findings have clear potential implications for future strategies in the management of clinical trials with aromatase inhibitors in the breast cancer.

Phosphorylated ER alpha, HIF-1 alpha, and MAPK Signaling As Predictors of Primary Endocrine Treatment Response and Resistance in Patients With Breast Cancer

Daniele Generali;Francesca M. Buffa
Investigation
;
Manuela Milani;
2009

Abstract

Analysis of clinical and molecular data shows that activated ERα form was an independent factor for sensitivity to chemoendocrine treatment, whereas HIF-1α and p44/42 MAPK were independent factors for resistance. Although further confirmatory analyses are needed, these findings have clear potential implications for future strategies in the management of clinical trials with aromatase inhibitors in the breast cancer.
2009
Generali, Daniele; Buffa, Francesca M.; Berruti, Alfredo; Brizzi, Maria P.; Campo, Leticia; Bonardi, Simone; Bersiga, Alessandra; Allevi, Giovanni; Milani, Manuela; Aguggini, Sergio; Papotti, Mauro; Dogliotti, Luigi; Bottini, Alberto; Harris, Adrian L.; Fox, and Stephen B.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11565/4062048
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