Cervical cancer is correlated with HPV infection. E6/E7 oncogenes play an important role leading transformation and maintenance of malignant cells. Our study aims to evaluate the expression of HPV mRNA E6/E7, genotypes and cytology in HIV positive (HPW) and negative women (HNW). Methods: A total of 328 HPV positive women, 64 HNW and 264 HPW, were unrolled. Cervical samples were tested with INNO-LiPa HPV genotyping (Innogenetics, Belgium), mRNA E6/E7 expression with APTIMA(Genprobe,USA) and cytology was evaluated according to Bethesda system 2001.

HPV mRNA E6/E7 expression, genotyping and cytology evolution in HIV-positive and negative women

MELILLI, EUGENIO;
2011

Abstract

Cervical cancer is correlated with HPV infection. E6/E7 oncogenes play an important role leading transformation and maintenance of malignant cells. Our study aims to evaluate the expression of HPV mRNA E6/E7, genotypes and cytology in HIV positive (HPW) and negative women (HNW). Methods: A total of 328 HPV positive women, 64 HNW and 264 HPW, were unrolled. Cervical samples were tested with INNO-LiPa HPV genotyping (Innogenetics, Belgium), mRNA E6/E7 expression with APTIMA(Genprobe,USA) and cytology was evaluated according to Bethesda system 2001.
2011
Proceeding of IAS 2011
Zanchetta, N; Rimoldi, Ms; Casolati, E; Orlando, G; Agarossi, A; Mazza, F; Fasolo, M; Melilli, Eugenio; Pagani, P; Pagano, F; Pileri, P; Berretta, R; Antonacci, C; Gismondo, Mr; Omodeo Zorini, E.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11565/3744453
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