This paper concentrates on the role of research network infrastructure in fostering the dissemination of innovation-related knowledge. It examines the structure of collaborative networks and of knowledge transfer between research, innovation and deployment activities in the field of Information and Communication Technology (ICT) for the European Union as a whole and for several European regions. Research networks complement diffusion networks by providing additional links and by increasing the number of the organisations involved in sharing and exchanging knowledge. Two types of actors are key players in these networks: hubs and gatekeepers. Hubs maintain the bulk of ties in the networks also helping the smaller and more isolated members remain connected. Gatekeepers bridge research and diffusion networks. Such organizations naturally offer greater policy leverage in establishing a European knowledge infrastructure. Moreover, strengthened inter-network connectivity among research and diffusion activities (deployment) would raise the effectiveness of European research in terms of accelerating innovation.