• A common core angiogenesis metasignature exists for different types of cancer • ELTD1 is upregulated in tumor endothelial cells and is a good prognostic marker • VEGF/DLL4 regulate ELTD1, which is important for tip cell function and angiogenesis • ELTD1 inhibition blocks tumor angiogenesis and substantially inhibits tumor growth

A Core Human Primary Tumor Angiogenesis Signature Identifies the Endothelial Orphan Receptor ELTD1 as a Key Regulator of Angiogenesis

Francesca M. Buffa
Supervision
2013

Abstract

• A common core angiogenesis metasignature exists for different types of cancer • ELTD1 is upregulated in tumor endothelial cells and is a good prognostic marker • VEGF/DLL4 regulate ELTD1, which is important for tip cell function and angiogenesis • ELTD1 inhibition blocks tumor angiogenesis and substantially inhibits tumor growth
2013
Masiero, Massimo; Costa Simões, Filipa; Dong Han, Hee; Snell, Cameron; Peterkin, Tessa; Bridges, Esther; Mangala, Lingegowda S.; Yen-Yao Wu, Sherry; Pradeep, Sunila; Li, Demin; Han, Cheng; Dalton, Heather; Lopez-Berestein, Gabriel; Tuynman, Jurriaan B.; Mortensen, Neil; Li, Ji-Liang; Patient, Roger; Sood, Anil K.; Banham, Alison H.; Harris, Adrian L.; Buffa, Francesca M.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11565/4062581
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