• A common core angiogenesis metasignature exists for different types of cancer • ELTD1 is upregulated in tumor endothelial cells and is a good prognostic marker • VEGF/DLL4 regulate ELTD1, which is important for tip cell function and angiogenesis • ELTD1 inhibition blocks tumor angiogenesis and substantially inhibits tumor growth
A Core Human Primary Tumor Angiogenesis Signature Identifies the Endothelial Orphan Receptor ELTD1 as a Key Regulator of Angiogenesis
Francesca M. Buffa
Supervision
2013
Abstract
• A common core angiogenesis metasignature exists for different types of cancer • ELTD1 is upregulated in tumor endothelial cells and is a good prognostic marker • VEGF/DLL4 regulate ELTD1, which is important for tip cell function and angiogenesis • ELTD1 inhibition blocks tumor angiogenesis and substantially inhibits tumor growth
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