• We identified genes regulated by hypoxia in prostate cancer cell lines. • In a cohort of primary tumours, the hypoxia regulated genes were reduced to a prognostic signature. • The mRNA abundance signature was prognostic of biochemical recurrence/metastatic recurrence in 11 independent cohorts.

Development and Validation of a 28-gene Hypoxia-related Prognostic Signature for Localized Prostate Cancer

Buffa F. M.
Supervision
;
2018

Abstract

• We identified genes regulated by hypoxia in prostate cancer cell lines. • In a cohort of primary tumours, the hypoxia regulated genes were reduced to a prognostic signature. • The mRNA abundance signature was prognostic of biochemical recurrence/metastatic recurrence in 11 independent cohorts.
2018
Yang, L.; Roberts, D.; Takhar, M.; Erho, N.; Bibby, B. A. S.; Thiruthaneeswaran, N.; Bhandari, V.; Cheng, W. -C.; Haider, S.; Mccorry, A. M. B.; Mcart, D.; Jain, S.; Alshalalfa, M.; Ross, A.; Schaffer, E.; Den, R. B.; Jeffrey Karnes, R.; Klein, E.; Hoskin, P. J.; Freedland, S. J.; Lamb, A. D.; Neal, D. E.; Buffa, F. M.; Bristow, R. G.; Boutros, P. C.; Davicioni, E.; Choudhury, A.; West, C. M. L.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11565/4061928
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