• We identified genes regulated by hypoxia in prostate cancer cell lines. • In a cohort of primary tumours, the hypoxia regulated genes were reduced to a prognostic signature. • The mRNA abundance signature was prognostic of biochemical recurrence/metastatic recurrence in 11 independent cohorts.
Development and Validation of a 28-gene Hypoxia-related Prognostic Signature for Localized Prostate Cancer
Buffa F. M.Supervision
;
2018
Abstract
• We identified genes regulated by hypoxia in prostate cancer cell lines. • In a cohort of primary tumours, the hypoxia regulated genes were reduced to a prognostic signature. • The mRNA abundance signature was prognostic of biochemical recurrence/metastatic recurrence in 11 independent cohorts.
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