• FABP3, FABP7, or ADRP induction by HIF-1α is essential for lipid storage in hypoxia • Lipid storage in hypoxia is due to fatty acid uptake, but not de novo lipid synthesis • Lipid droplets protect against ROS and support survival in hypoxia-reoxygenation • Inhibition of lipid accumulation impairs tumor growth in vivo
Fatty Acid Uptake and Lipid Storage Induced by HIF-1 alpha Contribute to Cell Growth and Survival after Hypoxia-Reoxygenation
Francesca M. BuffaInvestigation
;
2014
Abstract
• FABP3, FABP7, or ADRP induction by HIF-1α is essential for lipid storage in hypoxia • Lipid storage in hypoxia is due to fatty acid uptake, but not de novo lipid synthesis • Lipid droplets protect against ROS and support survival in hypoxia-reoxygenation • Inhibition of lipid accumulation impairs tumor growth in vivo
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