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• FABP3, FABP7, or ADRP induction by HIF-1α is essential for lipid storage in hypoxia • Lipid storage in hypoxia is due to fatty acid uptake, but not de novo lipid synthesis • Lipid droplets protect against ROS and support survival in hypoxia-reoxygenation • Inhibition of lipid accumulation impairs tumor growth in vivo

Fatty Acid Uptake and Lipid Storage Induced by HIF-1 alpha Contribute to Cell Growth and Survival after Hypoxia-Reoxygenation

Francesca M. Buffa
Investigation
;
2014

Abstract

• FABP3, FABP7, or ADRP induction by HIF-1α is essential for lipid storage in hypoxia • Lipid storage in hypoxia is due to fatty acid uptake, but not de novo lipid synthesis • Lipid droplets protect against ROS and support survival in hypoxia-reoxygenation • Inhibition of lipid accumulation impairs tumor growth in vivo
2014
CELL REPORTS
Bensaad, Karim; Favaro, Elena; Lewis, Caroline A.; Peck, Barrie; Lord, Simon; Collins, Jennifer M.; Pinnick, Katherine E.; Wigfield, Simon; Buffa, Francesca M.; Li, Ji-Liang; Zhang, Qifeng; Wakelam, Michael J. O.; Karpe, Fredrik; Schulze, Almut; Harris, Adrian L.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11565/4061919
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