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|Titolo:||Real-world data for the evaluation of transarterial radioembolization versus sorafenib in hepatocellular carcinoma: a cost-effectiveness analysis|
|Data di pubblicazione:||9999|
|Autori interni:||ROGNONI, CARLA|
|Autori:||Rognoni, Carla; Ciani, Oriana; Sommariva, Silvia; Tarricone, Rosanna|
|Rivista:||VALUE IN HEALTH|
|Abstract:||Objectives: To perform a cost-effectiveness analysis comparing the use of transarterial radioembolization (TARE) with that of sorafenib in the treatment of patients with intermediate or advanced hepatocellular carcinoma (HCC) according to the Barcelona Clinic Liver Cancer staging system. Methods: Patient-level data were consecutively recorded and collected at three oncology centers in Italy. A propensity score matching was performed to compare patients with similar clinical characteristics who underwent TARE or sorafenib treatment. Clinical data from the matched cohorts were used to populate a Markov model to project, on a lifetime horizon, life years, qualityadjusted life years, and economic outcomes associated with TARE and sorafenib for both intermediate and advanced HCC stages. Results: Starting from data covering 389 and 241 patients who underwent TARE and sorafenib treatment, respectively, the propensity score matching yielded a total of 308 matched patients. For intermediatestage patients, the model estimated for TARE versus sorafenib an incremental cost-utility ratio of €3,302/QALY (incremental costeffectiveness ratio of €1,865 per life year gained), whereas for patients in advanced stage TARE dominated (lower costs and greater health improvements) compared with sorafenib. Conclusions: From an Italian health care service perspective, TARE could be a costeffective strategy in comparison with sorafenib for patients with intermediate or advanced HCC. The results from forthcoming randomized controlled trials comparing TARE with sorafenib will be able to confirm or reject the validity of this preliminary evaluation. In the meantime, decision makers can use these results to control and coordinate the diffusion of the technology.|
|Appare nelle tipologie:||01 - Articolo su rivista Scientifica|
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